Defects to the IFT-A complex of proteins (e.g., WDR35, IFT122, IFT43, IFT172, IFT140 and WDR19), can present with renal disease phenotypes such as chronic renal failure, NPHP, and renal cysts (63, 198–203) and, in some cases, isolated NPHP or NPHP-like nephropathy (63). This evidence concerns the gene IFT172 and kidney disorder.