LUZP1 and Townes-Brocks syndrome: Importantly, interactions between mutant SALL1 and LUZP1 target LUZP1 for degradation leading to the disruption of both ciliogenesis and SHH signaling through reduced F-actin polymerization, indicating that dysregulation of centrosomal actin cytoskeleton contributes to the pathogenesis of TBS (222).