KCNA3 and early-onset autosomal dominant Alzheimer disease: High levels of microglial Kv1.3 expression are associated with a pro-inflammatory profile of microglia in various neuropathological conditions, including Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, and stroke, and microglial pro-inflammatory responses are significantly reduced by pharmacological blockade or genetic deletion of microglial Kv1.3 (Rangaraju et al., 2009; Chen et al., 2017; Maezawa et al., 2018; Sarkar et al., 2020).