CXCL8 and amyotrophic lateral sclerosis: A meta-analysis study including 25 case-control with 812 ALS patients and 639 control subjects, showed significant elevations of peripheral blood inflammatory cytokines such as TNF-α, TNFR1, IL1β, IL-6, IL-8, and VEGF compared to healthy individuals (Hu et al., 2017).