KRAS and acute lymphoblastic leukemia: The sequential mutation events in ALL were further explained by combining scDNA-seq and protein analysis, where a study found that the lineage-related mutations (ETV6, IKZF1, and PAX5) occurred early, and kinase-activating mutations (JAK1, JAK2, KRAS, NRAS, FLT3) were acquired in a later evolutionary trajectory [49] (Fig. 3c).