Similarly, in AML, a study revealed that the order of mutation gain implied epigenetic modifiers such as DTAI (DNMT3A, TET2, ASXL1, and/or IDH1 or IDH2) are the most prevalent AML initiating mutation, and combinations of those mutations (e.g., DNMT3A-IDH2) may contribute to clonal dominance [15] (Fig. 3c). This evidence concerns the gene IDH2 and acute myeloid leukemia.