This kind of m-LSC exhibited a unique immunophenotype (CD34+, CD4+, CD11b−, CD14−, CD36−) which is fundamentally different from the previously well-described primitive LSC (p-LSC) type [108, 59] while these two types of LSCs can co-reside in the same AML patient (Fig. 6). The gene discussed is CD36; the disease is acute myeloid leukemia.