In summary, our findings underscore the critical role of GPR68 in the autocrine interplay between the Warburg Effect, acidic TME, and protection from ferroptosis in GBM cells, suggesting that GPR68 inhibitors like ogremorphins may offer an appealing therapeutic strategy, especially in combination with the frontline therapies such as TMZ and ionizing radiation. The gene discussed is GPR68; the disease is glioblastoma.