FOXD2 and central nervous system cancer: Group 4 reports 58 DE lncRNAs (Additional file 2: Table S8), of which FOXD2-AS1 has been associated with resistance to chemotherapeutic treatments in gliomas [35], TIPARP antisense 1 (TIPARP-AS1) was demonstrated to regulate AhR signaling, which in turn is involved in neuroendocrine pathways such as those that control the brain-pituitary-interrenal and gonadal axes [36, 37] and long intergenic non-protein coding RNA 1615 (LINC01615), biomarker of head and neck squamous cell carcinoma [38].