APOH and bacterial infectious disease with sepsis: Previous research has shown that APOH-deficient mice (APOH−/−) developed earlier onset of severe septicaemia than WT mice (male APOH−/−: 71.4% vs. male WT: 28.6%, with a severity score of ≥ 3) within 24 h following an intravenous injection of E. coli [10].