KL and lung adenocarcinoma: Therefore, to explore the underlying mechanisms for the distinct therapeutic response, we used KRASG12DLKB1−/− (hereafter referred to “KL”, previously established from a spontaneously arising lung adenocarcinoma in the KrasG12DLkb1fl/fl mouse model, (Additional file 3: Fig. S1A) and KRASG12DTP53−/− (hereafter referred to “KP”) murine lung adenocarcinoma cell lines [14, 15] for further analyses.