To illustrate the cytotoxic effects of FAK inhibition on tumor cells, we utilized human NSCLC cell lines with LKB1-mutant (A549), LKB1-WT (H1299), mouse lung cancer cell line with LKB1-wild type (KP) and mouse lung cancer cell line with LKB1-loss (KL). The gene discussed is PTK2; the disease is non-small cell lung carcinoma.