ITGAM and neoplasm: Tumor-associated neutrophils (TANs) and polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs, CD45+CD11b+Ly6G+Ly6Clow), which suppressed T cells function to help form immunosuppressive TME [17], were significantly highly infiltrated in KL tumors (Fig. 2H and J).