In addition, we used the nematode Caenorhabditis elegans (C.elegans) because of its short life span, transparent body, simple symbiotic system, easily recognizable behavior and presence of most iron transporter genes to provide further mechanical validation of the role of p-tau hyperphosphorylation in AD-like impairment and to test the ability of probiotics to lower p-tau in the rodent model. This evidence concerns the gene MAPT and Alzheimer disease.