UCP1 and metabolic dysfunction-associated steatotic liver disease: Simultaneously, another group proved that uncoupling protein 1 (UCP1) KO mice exhibited higher succinate levels of liver tissues than the wild-type mice as a result of diminished capacity to clear succinate from the circulation and succinate-SUCNR1 regulated activation in liver HSC populations, thus exacerbating the fibrosis progress of the non-alcoholic fatty liver disease [40].