In patients with SLE, the polyreactive B cells produce a range of autoantibodies, including anti-double stranded DNA (dsDNA), anti-Smith (Sm), anti-ribonucleoprotein (RNP), anti-Ro, anti-La, anti-phospholipid and anti-nuclear antigen (ANA) antibodies [10]. The gene discussed is CALR; the disease is systemic lupus erythematosus.