Second, although the results obtained from in vitro co-culture system have proved that tumorous IRE1α robustly potentiated the anti-tumor capacity of CD8+T cells, and the killing effect seems to be synergic compared to either the mono-treatment with sublethal HA15 or the only presence of T cells, additional system that could testify antigen-specific killing of CD8+T cells should be employed in the future to provide more convincing evidence. This evidence concerns the gene CD8A and neoplasm.