CD8A and melanoma: To further figure out whether HA15 regulated melanoma growth by modulating the anti-tumor capacity of CD8+T cell, specific antibody targeting CD8 were injected intraperitoneally to block CD8+T cells systemically in immunocompetent C57BL/6 mice burdened with B16F10 melanoma tumor (Fig. 2F; Additional file 1: Fig. S2F).