The expression of EGFP-K-Ras(V12) and its interaction with PI3-Kα resulted in marked activation of Akt not only in PANC-1 pancreatic carcinoma cells but also in Colo-699 and in HEK293 cells, and support the notion, that PI3-Kα-Akt is one of the main effector pathways of K-Ras(V12). The gene discussed is AKT1; the disease is exocrine pancreatic carcinoma.