KRAS and exocrine pancreatic carcinoma: By stable expression of EGFP-K-Ras(V12) in PANC-1 pancreatic carcinoma cells, we previously demonstrated that K-Ras(V12) induced morphological alterations towards a mesenchymal, invasive phenotype, with enhanced cellular motility and invasion, altered actin filament organization, and reduced cell-cell-contact formation [21, 22].