Interestingly, the mean value of Akt3 protein expression in pancreatic carcinoma cells exhibiting homozygous K-Ras mutation is 1.98 and thus twofold higher than the mean value of 1.01 for wild type/heterozygous mutated cell lines, including Capan-2, which showed inconsistent expression in the four experiments. This evidence concerns the gene KRAS and exocrine pancreatic carcinoma.