Moreover, oncogenic K-Ras(V12) induced the expression of NCAM and polysialyltransferases in pancreatic carcinoma cells, which leads to reduced E-cadherin adhesiveness and increased cell migration by interaction of polysialylated NCAM to E-cadherin and sterical inhibition of homophilic E-cadherin trans-interactions [22]. This evidence concerns the gene KRAS and exocrine pancreatic carcinoma.