Seven exosomal miRNAs, including 10b-5p, 221-3p, 223-3p, 10b-5p, 221-3p, 223-3p, and 21–5, were identified by Ghosh and colleagues in 2020 as sensitivity indicators for the early identification of HCC independent of HCV origin, particularly HCCs linked with low AFP. The gene discussed is AFP; the disease is hepatocellular carcinoma.