H&E staining, immunohistochemical staining of Ki67, Sirius red staining and Oil red O staining also revealed that DEN/HFD-treated SMAMyD88−/− mice had reduced inflammatory cell infiltration, steatosis, cell proliferation, fibrosis and fat accumulation compared with MyD88fl/fl mice (Fig. 4J). The gene discussed is MKI67; the disease is steatosis.