In this study, the mutation of the ALS pathogenesis-associated progranulin (GRN) gene c.1352C > T (p.P451L) and the ErbB4 gene has a heterozygous mutation c.256 T > C(p.Y86H) was found in our patient during the analysis of FTD-related genes. The gene discussed is GRN; the disease is amyotrophic lateral sclerosis.