By univariate analysis, male, age, diabetes, presence of abdominal pain, encephalopathy, SIRS, bacterial or fungal infections, AKI, ARDS and shock, serum ALT, AST, TBIL, ALP, GGT, LDH, amylase, lipase, BUN, creatinine, cystatin-C, potassium, CK, CK-MB, troponin I, BNP, PT, APTT, TT, CRP, procalcitonin, IL-6, SAA, ESR, ferritin levels, and viral load, low platelet count, hemoglobin, albumin, fibrinogen, and PTA were identified as risk factors for the prognosis of SFTS patients (Supplementary Table 2). The gene discussed is ESR1; the disease is Encephalopathy.