The presence of encephalopathy (adjusted OR 5.584, 95% CI 2.322–13.428; P < 0.001), SIRS (adjusted OR 2.885, 95% CI 1.226–6.786; P = 0.005), bacterial or fungal infections (adjusted OR 2.249, 95% CI 1.157–5.710; P = 0.017), creatinine (adjusted OR 1.010, 95% CI 1.005–1.015; P < 0.001), IL-6 (adjusted OR 1.002, 95% CI 1.001–1.003; P = 0.040) were identified as independent predictors for the in-hospital mortality of SFTS patients on multivariate analysis (Table 2). This evidence concerns the gene IL6 and Encephalopathy.