In patients with HNSC, LIHC, LUAD and SKCM, the survival time of patients with high LDHB expression was shorter than that of patients with low LDHB expression, and in patients with GBM and LGG, the survival time of patients with low LDHB expression was shorter than that of patients with high LDHB expression. The gene discussed is LDHB; the disease is glioblastoma.