The prognostic significance of VWA5A on overall survival (OS) was also confirmed in all cases with BC (p = 0.0009; HR 0.82; 95% CI 0.73–0.92) and ER+ BCs (p = 0.0003; HR 0.74; 95% CI 0.62–0.87), but not in HER2+ and TNBC cases (Supplementary Fig. S4). This evidence concerns the gene ESR1 and breast cancer.