Targeting the ZZ-domain of p62 by small molecule ligand, YOK1104 (Cha-Molstad et al. 2017), induced the self-polymerization of p62 and enhanced co-localization of p62 with LC3B and LAMP1 in HPV− HNSCC cells compared to HPV16+ HNSCC cells. Here, MAP1LC3B is linked to head and neck squamous cell carcinoma.