Based on their experiments, Lee et al. concluded that upon radiation treatments HPV16+ HNSCC cells fail to induce autophagic LC3 flux, as assessed by LC3B western blotting in cells that had been treated with Bafilomycin A1, and undergo apoptotic cell death (Lee et al. 2021). This evidence concerns the gene MAP1LC3B and head and neck squamous cell carcinoma.