On the other hand, autophagy impairment in tumor cells may lead to decreased antigen presentation (Zhong et al. 2016; Münz 2021; Jiang et al. 2021b) and an increased degradation of STING by HPV16 could help the HNSCC cells evade the immune system (Luo et al. 2020). This evidence concerns the gene STING1 and neoplasm.