Besides revealing a correlation between STING signaling and enhanced CD4+/CD8+ T cell infiltration, this group also noted that transfection of three HNSCC cell lines (93VU147T, UMSCC47, and FaDu) with an HPV16 E7 expression plasmid inhibited STING-induced transcription of IFN-I target genes. This evidence concerns the gene CD4 and head and neck squamous cell carcinoma.