NOTCH1 and multiple symmetric lipomatosis: As explained before, CNC-anticancer activity might be attributed to ROS production22 which has been involved in the regulation of Notch1 signaling pathwa23, induction of autophagy and apoptosis through ROS/JNK signaling pathways24,31,32 These observations are may provide more evidence for CNC as a promising chemotherapeutic agent in treating MSL subtype of TNBC.