Indeed, low ceruloplasmin levels and brain iron accumulation are associated with both common and rare neurodegenerative diseases, such as Parkinson’s disease, Alzheimer’s disease and Wilson disease16,55,60,62–65, and CP replacement therapy might represent as a potential adjuvant therapy in at least some of these conditions and in a relevant subsets of patients. Here, CP is linked to early-onset autosomal dominant Alzheimer disease.