Our investigation revealed a strong association between high F2R expression and poorer survival outcomes, high F2R expression is associated with poor prognosis of GC, F2R gene is an oncogene, when it is highly expressed in tissues, it promotes the malignant progression of GC cells and shortens the survival time of patients, positioning F2R as a promising prognostic biomarker. This evidence concerns the gene F2R and gastric cancer.