The Normal/NAFLD cluster samples also showed the presence of hepatocytes that have high expression of CYP2A6, CYP2A7, CYP2B6, CFHR1/3 and GSTA1 (Hepatocytes_14) and are characteristic of hepatocytes involved in xenobiotic, steroid, fatty acid and drug metabolism (Figs. 4D and S3F). Here, CYP2A7 is linked to metabolic dysfunction-associated steatotic liver disease.