We have previously reported that the splicing factor Ser/Arg-rich splicing factor 3 (SRSF3) is proteolytically degraded in fatty liver disease29, so we obtained 43 frozen liver samples of individuals with no known history of liver disease, or histologically verified non-alcoholic fatty liver disease (NAFLD) or non-alcoholic steatohepatitis (NASH) from the University of Minnesota Liver Tissue and Cell Distribution Service. This evidence concerns the gene SRSF3 and metabolic dysfunction-associated steatohepatitis.