The 36 genes harboring the common late SEs show enrichment in immune response genes and RHO GTPase signaling (Fig. 8B) that is not observed in the early SE changes and are associated with chronic liver disease, hepatitis, fatty liver disease, NASH, obesity, and many inflammatory and infectious diseases (Fig. 8C). Here, RHO is linked to obesity due to melanocortin 4 receptor deficiency.