KHDRBS1 (Sam68) and SRSF3 regulate gluconeogenesis9 and loss of SRSF3, A1CF, SRSF2, SRSF1, and SRSF10 causes steatosis and changes in lipid metabolism74 but loss of NONO, the binding partner for SFPQ, increases fat catabolism and protects against steatosis75. The gene discussed is KHDRBS1; the disease is steatosis.