SRSF3-dependent SE were almost twofold enriched in the obese group compared to the lean healthy group (OR 1.88, p = 0.0003), but were very significantly depleted in NAFLD and NASH groups (OR 0.19, p < 0.0001 and OR 0.00, p < 0.0001, respectively). Here, SRSF3 is linked to metabolic dysfunction-associated steatohepatitis.