Mechanistically, the peroxisome proliferator-activated receptor α (PPARα)-mediated specific reduction in the sarco/endoplasmic reticulum Ca2+-ATPase 2 (SERCA2) pump contributes to the attenuated osteocyte Ca2+ oscillatory dynamics in T2D skeletons, characterized by fewer and weaker Ca2+ spikes with prolonged Ca2+ uptake. This evidence concerns the gene PPARA and type 2 diabetes mellitus.