To further investigate the role of osteocytic SERCA2 in the T2D-mediated deterioration of bone mechano-responsiveness, we generated a conditional osteocyte SERCA2 knock-in mouse model (SERCA2 cKI) by crossing SERCA2flox/flox mice with DMP1-Cre mice (Fig. S16). The gene discussed is ATP2A2; the disease is type 2 diabetes mellitus.