Remarkably, no significant differences in delta DAS28-CRP (p = 0.2) (Fig. 5a), delta health assessment questionnaire (HAQ) (p = 0.5) (Fig. 5b), number (p = 0.6) or severity (p = 0.9) of RA/PsA relapses were observed across groups when classifying by DAS28 or physician-dependent criteria (Fig. 5c, d). This evidence concerns the gene CRP and rheumatoid arthritis.