Dysfunctional and exhausted monocytes from VEXAS (clusters 14 and 20) showed significantly higher expression of CXCR3, CXCR5, CCR4 and CCR7 compared to VEXAS-like, MDS and healthy controls (Fig. 2G and Supplementary Fig. 4D). The gene discussed is CXCR5; the disease is myelodysplastic syndrome.