The majority of VEXAS individuals had recurrent fevers, arthralgias/arthritis, neutrophilic dermatosis and cutaneous vasculitis, pulmonary involvement (Supplementary Table 1), macrocytic anemia (Fig. 1C), leukopenia, mainly lymphocytopenia and monocytopenia, and increased C-reactive protein and lactate dehydrogenase levels (Fig. 1D), and bone marrow vacuolization restricted to myeloid and erythroid precursor cells (Fig. 1E). This evidence concerns the gene CRP and arthritic joint disease.