For example, an integrated analysis of four immune-mediated disorders (rheumatoid arthritis, inflammatory bowel disease, interstitial lung disease, and Sjogren’s syndrome) identified two shared pro-inflammatory states (CXCL10+/CCL19+ and SPARC+/COL3A1+ fibroblasts) that were also detectable in atopic dermatitis38. This evidence concerns the gene SPARC and rheumatoid arthritis.