PSEN1 and Alzheimer disease: Here, we used the AppNL-G-F/NL-G-F knock-in (APPKI) mouse model of AD developed by Saito et al. (2014) that contains a single copy knock-in of human APP with the Swedish (K670N, M671L), Arctic (E693G), and Beyreuther/Iberian (I716F) FAD mutations.