Our Mendelian randomization and colocalisation analyses found little evidence for a causal role for serum glycoprotein Nmb in development of six type 2 diabetes-related cancers (colorectal, breast, endometrial, gallbladder, liver, and pancreatic cancers), though the tissue-specific relevance or predictive utility of serum glycoprotein Nmb in type 2 diabetes-related cancer risk should be further investigated. Here, ART4 is linked to cancer.