In summary, we performed an analysis of samples from a weight-loss intervention trial and found that nine cancer-related proteins were associated with intervention status (glycoprotein Nmb; furin; Wnt inhibitory factor 1; toll-like receptor 3; pancreatic prohormone; erb-b2 receptor tyrosine kinase 2; hepatocyte growth factor; endothelial cell specific molecule 1 and Ret proto-oncogene). This evidence concerns the gene FURIN and cancer.