Hence, the Bregs identified in our study, bearing a resemblance to B-2 cells, diverge from those observed by Lan Wu et al. In Lan Wu et al.’s investigation, the Bregs were primarily located in pericardial adipose tissues, conferring protection against myocardial ischemia mainly through paracrine IL-10 release. Here, IL10 is linked to myocardial ischemia.