We focused on three targets relevant to Esophageal Squamous Cell Carcinoma: TGF-beta receptor type-2 (TGFBR2) [36], Cellular tumor antigen p53 (TP53) [37], and Polyunsaturated fatty acid lipoxygenase (ALOX12) [38]. This evidence concerns the gene TP53 and esophageal squamous cell carcinoma.