LDLR and atherosclerosis: To compare the performance of TRAP-Seq and scRNA-Seq for detecting SMC-enriched genes, we utilized previously published scRNA-Seq from the same atherosclerosis mouse model (Ldlr−/−, ApoB100/100)25 and applied the same discovery cut-offs (FDR < 0.05 and fold change > 1.5, calculated from pseudobulk in the case of scRNA-Seq).