We identified several variants within the ITIH4 gene that have been significantly associated with cardiovascular phenotypes, including heart rate (rs17331178, 3:52847544_C/A, Pvalue 9.44e−12), pulse pressure (rs2071044, 3:52847601_C/T, P value 1.00e−11), and CAD (rs77347777, chr3:52848207:C:T, P value 8.86e−11) (Cardiovascular Disease Knowledge Portal; https://cvd.hugeamp.org/, March 2023) (see Supplementary material online, Figure S7A and Table S28). This evidence concerns the gene ITIH4 and coronary artery disorder.