The gene list included well-known atherosclerosis-associated genes Serpina3,42Cemip,43Thbs1,44Lum,45 and Spp146,47 but also novel genes without previous association to SMC function in atherosclerosis, such as Anxa4, Cd276, Itih4, Myof, Pcdh11x, Rab31, Serpinb6b, Slc35e4, Slc8a3, and Spink5 (see Supplementary material online, Table S17). The gene discussed is ITIH4; the disease is atherosclerosis.