ITIH4 and myocardial infarction: Only ITIH4 was linked to splicing variants associated with CAD, leading to its selection for in-depth study; previous research has indicated ITIH3’s role in myocardial infarction.57 Additionally, ITIH3 has been recognized as a potential protein biomarker for CAD incidence in patients with familial hypercholesterolaemia.58 These findings suggest that further analysis of the ITIH family is warranted.