ITIH4 and peripheral arterial disease: The functional consequences of this remain unknown but based on the observed direction of association, it appears that the protective T allele, promoting exon 22 skipping, results in a pQTL effect in the blood.28 The pQTL association for rs77347777 was also seen by Ferkingstad et al.69 who additionally found that ITIH4 plasma protein level shows a positive correlation with coronary and peripheral artery disease (P value 4.80e−27 and 4.00e−27, respectively).