Finally, to evaluate the functional role of ITIH4 in SMCs, we interrogated the published data on atherosclerosis-relevant cellular phenotypes studied across 151 human aortic SMC donors.32,33 In this data set, a negative correlation was observed between ITIH4 expression level and SMC calcification (see Supplementary material online, Figure S7D). The gene discussed is ITIH4; the disease is atherosclerosis.