Only ITIH4 was linked to splicing variants associated with CAD, leading to its selection for in-depth study; previous research has indicated ITIH3’s role in myocardial infarction.57 Additionally, ITIH3 has been recognized as a potential protein biomarker for CAD incidence in patients with familial hypercholesterolaemia.58 These findings suggest that further analysis of the ITIH family is warranted. This evidence concerns the gene ITIH4 and coronary artery disorder.