This is in line with a recent study on 91 autopsy-inconclusive SCD cases where cardiomyopathy-associated genes harboured 70% of clinically actionable variants.13 Genetic findings correlated with the phenotype in only two cases, both with ACM; FLNC and TMEM43 were the genes involved, which emphasizes the arrhythmic risk of these specific disorders.14,15 Although our cohort is large, not all cases of SCD in the UK are referred to our centre and this introduces a bias. The gene discussed is TMEM43; the disease is Schnyder corneal dystrophy.