We identified APP pathway-related ligand receptor proteins, including APP and CD74 (CD74 Antigen), with upregulated protein expression in pathological tissue sections of psoriatic skin (Supplementary Table 5; Psoriasis/Normal skin Ratio in CD74 protein: 1.202; Psoriasis/Normal skin Ratio in MIF protein: 1.239). Here, MIF is linked to psoriasis.