IL7 and colorectal carcinoma: In conclusion, the above findings not only reveal that IL7 regulated by GM has the potential to serve as a cancer vaccine adjuvant and a novel immune checkpoint in CRC, but also emphasize the great feasibility of in-depth study of certain specific gut-microbial subspecies including Lactobacillus reuteri clade IV strains for the realization of microecological therapies for CRC.