Our study adds support for the key role of tau in epilepsy [11, 44, 60]: our results suggest that tau may be a key upstream regulator involved in the decrease of many neuronal proteins including axon, synapse (particularly synaptic vesicle), microtubule, and mitochondrial proteins in epilepsy and that tau may mediate many of these effects via protein–protein interaction. Here, MAPT is linked to epilepsy.