SYN1 and Alzheimer disease: Some examples include: Synaptophysin (SYP) is decreased in both epilepsy [39] and AD [32]; SLC17A7 (also known as VGLUT1) is decreased in select TLE cases [16] and AD [23]; DNM1L interacts with tau and accumulates in tau aggregates in AD [31] and is genetically linked to epilepsy [9]; SYN1 is decreased in AD [2] and genetically linked to seizures [29].