Considering the crucial role of FcεRI signaling in the responsiveness of MCs to IgE, Hemme et al. applied a Bruton tyrosine kinase inhibitor (acalabrutinib) to study the significance of the FcεRI receptor signaling in progression of atherosclerosis in Ldlr− /− mice on high-fat diet (HFD) 2 months while taking acalabrutinib. This evidence concerns the gene IGHE and atherosclerosis.