The results of Houde et al. on ApoE−/−, mMCP-4−/−, and ApoE−/−mMCP-4−/− mice in different stages of atherosclerosis showed that mMCP-4 inhibition may reduce plaque progression in the earlier phases of atherosclerosis and stabilize the advanced plaques [80]. The gene discussed is APOE; the disease is atherosclerosis.