Among them, MRPL12, as a component of the mitochondrial ribosomal protein complex (Hu et al. 2023), is an RNA-binding protein, and in vitro experiments demonstrated that down-regulation of its endogenous expression significantly inhibited the proliferation and migration of breast cancer (Liu et al. 2021a, b); its expression pattern was correlated with the poor prognosis of the patients. The gene discussed is MRPL12; the disease is breast carcinoma.