They first characterized fundamental uptake changes with SERT and the norepinephrine transporter (NET) in mice using fluvoxamine and citalopram, and found that both SERT and NET contribute to the active clearance of serotonin in the CA3 region of the hippocampus, which is a very important region studied in depression [9, 60]. This evidence concerns the gene SLC6A4 and depressive disorder.