SCN5A and epilepsy: In HEK293 cells co-expressing epilepsy-related Slack mutant variants (G288S, R398Q) (Rizzo et al., 2016; Barcia et al., 2019) and NaV1.5/6NC, expression of Slack’s C-terminus significantly reduced whole-cell current densities of SlackG269S and SlackR398Q (Figure 7A and B), supporting that disrupting the Slack-NaV1.6 interaction can indeed reduce current amplitudes of Slack mutant variants, which may protect against seizures induced by Slack mutant variants.