BRD2 and obesity due to melanocortin 4 receptor deficiency: Obesity leads to hormonal imbalance directly orindirectly as it affectssex hormone-binding globulin (SHBG)and decreases thelevels of free testosterone as well as follicle-stimulating hormone (FSH) andluteinizing hormone (LH) which ultimately impact spermatogenesis (Shpakov et al., 2018).Hypogonadotropic-hypoestrogenic-hypogonadism is caused by the aromatization ofsteroids to estrogens in peripheral tissues, which results in a significant dropin testosterone levels and a rise in estradiol (Corradi et al., 2016).