Several studies have revealed that obesity has an impact on spermatogenesis andSertoli cell activity, as evidenced by the considerable decrease in inhibin Bconcentration compared with the decline in FSH levels (Leisegang et al., 2021; Saikia et al., 2019).Reports show that overweight males had lower levels of inhibin B and higheramounts of estradiol. The gene discussed is BRD2; the disease is obesity disorder.