The Notch1 pathway is involved in neoangiogenesis and revascularization of a failing heart.28 It limits the extent of ischemic injury,28 reduces fibrosis,29 and improves cardiac function.30 Several protein EpiScores associated with CVD in our study, such as SELE and C5, have also been shown to be associated with stroke and ischemic heart disease in our previous work.20 This evidence concerns the gene C5 and Stroke.