INS and diabetes mellitus: In this age group, we noticed suggestive causal association between BMI with increased risk of DM (OR = 1.217, 95% CI 1.020-1.452, p = 0.029), and lower fasting glucose (OR = 0.963, 95% CI 0.936-0.991, p = 0.009), as well as marginally significant association with fasting insulin (OR = 0.923, 95% CI 0.872-0.977, p = 0.006) in females, not in males.