In multivariable MR (Figure 3; Supplementary Table 5), in men, after adjusting for sex-specific IVs for adult BMI, testosterone and SHBG, there was a suggestive negative association between newborn BMI with CAD (OR = 0.862, 95% CI 0.751-0.989, p = 0.034) and MI (OR = 0.864, 95% CI 0.752-0.991, p = 0.037), while an increased effect size between five-to-eight-year childhood BMI and MI (OR = 1.120, 95% CI 1.023-1.226, p = 0.014). This evidence concerns the gene SHBG and coronary artery disorder.