However, when considering additional factors, including hs-CRP, HGB, TG, Scr, HbA1c, BUN, UA, WBC, PLT, antihypertensive drug use, antihyperglycemic drug use, and antihyperlipidemic drug use, the association between the non-HDL-c/HDL-c ratio and stroke risk became statistically insignificant (HR=1.022, 95% CI: 0.964-1.083). This evidence concerns the gene CRP and Stroke.