In order to better understand the binding characteristics of GPR119 and agonist and its activation mechanism, this paper analyzes the structure of GPR119 binding agonist APD597 and the downstream G-protein trimer complex interacting with it were analyzed by single particle cryo-electron microscopy technique, which can provide the structure and theoretical basis for the development of therapeutic drugs for type 2 diabetes therapeutic drugs. The gene discussed is GPR119; the disease is type 2 diabetes mellitus.