PDK1 and neoplasm: It has been reported [86] that significantly downregulated miR-379 in OS tissues and cell lines (MG-63, U2OS, SOSP-9607, SAOS-2) can significantly upregulate PDK1 expression, and high expression of PDK1 promotes tumour cell proliferation and migration, indicating that PDK1 is a direct target of miR-379.