SLC2A1 and neoplasm: The authors [26] also found that P53 mutations in SaOS-2 OS cell line impair the inhibitory effect of wild-type p53 on the transcriptional activity of GLUT1 and GLUT4 gene promoters, thereby increasing the expression level of GLUT protein and the ability of tumour cells to uptake glucose, leading to faster proliferation of tumour cells.