While previous studies, including our current investigation, have demonstrated that environmental toxicants like TCDD or BaP induce proinflammatory reactions, it is noteworthy that endogenous AhR ligands, such as FICZ, and the direct binding of tapinarof to AhR yield anti-inflammatory responses in psoriasis-like models (Di Meglio et al., 2014). The gene discussed is AHR; the disease is psoriasis.