Transthyretin amyloidosis (ATTR) encompasses two distinct pathologies based on whether the amyloid fibrils originate from the intact molecule of TTR: wild-type ATTR (ATTRwt), also known as senile systemic amyloidosis, or from mutations occurring in the TTR gene (ATTRv) (3). The gene discussed is TTR; the disease is Familial transthyretin-related amyloidosis.