Apoptosis and antiproliferation potency were increased in BPH versus non-BPH stromal cells. There was downregulation of transforming growth factor B1 in both populations. Fibroblast growth factor 2 presence increased the cell’s sensitivity to Pyegeum africanum. However, the presence of VEGF, DHT, or beta-estradiol decreased the antiproliferative activity of Pyegeum africanum. This evidence concerns the gene VEGFA and benign prostatic hyperplasia.