CVD: Cardiovascular diseases; GUS: Genitourinary syndrome; T2DM: Type 2 diabetes mellitus; HRT: Hormonal replacement therapy; HT: Hormonal therapy; MT: Menopausal transition; FSH: Follicle-stimulating hormone; LH: Luteinizing hormone; BED: Binge eating disorder; PCOS: Polycystic ovarian syndrome. The gene discussed is PLOD1; the disease is diabetes mellitus.